Congenital heart disease (CHD) is the most common birth defect and in most cases idiopathic. Genetic causes account for up to 35% of patients with CHD [1] are linked to increased operative risk and mortality [2]. One of the most common genetic abnormalities is a deletion in 22q11 [3], which affect 1 in 2,000-4,000 live births. This results in a wide spectrum of phenotypes including CHD, palatal abnormalities, immunodeficiency, hypoparathyroidism, dysmorphic facies, and developmental delay [4]. Conotruncal abnormalities are the most common cardiac defects and are found in 75% of patients with 22q11 deletions [3]. Deletions in 22q11 are found in 15% of patients with tetralogy of Fallot (TOF) [5], 50% with interrupted aortic arch (IAA), and 35% with truncus arteriosus (TA) [5]. Conoventricular ventricular septal defects (VSD) are associated with 22q11 deletion in roughly 5% of patients [5].

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