Posted in Research Article

Periconceptional Maternal Folic Acid Supplementation Mediate DNA Methylation Affecting Off spring Health

Folate, VitB12, choline, betaine and methionine both participate in the one-carbon metabolism (FOCM). Under the action of FOCM cycle enzymes, above-mentioned micronutrients convert to essential…

Continue Reading... Periconceptional Maternal Folic Acid Supplementation Mediate DNA Methylation Affecting Off spring Health
Posted in Research Article

Aspirin Responsive Sticky Platelet Mediated Thrombophilia Caused by Gain of Function Mutations in the Thrombopoietin, JAK2 and MPL Genes in Hereditary and Acquired Essential Thrombocythemia

In the 1990s it was known that thrombopoietin (TPO) stimulates megakaryocyte production both in vitro and in vivo [1-3]. Size, number, and mean geometric ploidy…

Continue Reading... Aspirin Responsive Sticky Platelet Mediated Thrombophilia Caused by Gain of Function Mutations in the Thrombopoietin, JAK2 and MPL Genes in Hereditary and Acquired Essential Thrombocythemia
Posted in Research Article

Genetic Testing and Neurodevelopmental Follow Up in Patients with Conotruncal Abnormalities

Congenital heart disease (CHD) is the most common birth defect and in most cases idiopathic. Genetic causes account for up to 35% of patients with…

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Posted in Case Report

Management of Arteriovenous Malformations in Pediatric Population: about two Cases

The annual incidence of brain arteriovenous malformations (AVMs) in the general population is estimated between 0.1 and 4% with an annual hemorrhage rate between 2…

Continue Reading... Management of Arteriovenous Malformations in Pediatric Population: about two Cases